Observation of the Treatment Effect of 1.6-diphosphate on Neonatal Hypoxic-ischemic Encephalopathy Combined with Myocardial Damage
- VernacularTitle:1,6-二磷酸果糖治疗新生儿缺氧缺血性脑病合并心肌损害疗效观察
- Author:
Xianxia LI
;
Li ZHANG
- Publication Type:Journal Article
- Keywords:
1,6-diphosphate;
Newborn;
Hypoxic-ischemic encephalopathy;
Myocardial damage
- From:
Journal of Medical Research
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of 1,6-diphosphate(FDP)on neonatal hypoxic-ischemic encephalopathy(HIE)combined with myocardial damage.Methods 62 cases of HIE in newborn with myocardial damage were randomly divided into two groups:32 cases of the treatment group and 30 cases of the control group.Control group were giren conventional treatment and the treatment group were giren FDP 250mg /(kg?d)by intravenous drip for 10 days for 1 course of treatment.Each case was tested serum creatine kinase(CK)and isoenzyme(CK-MB)within hospitalization 12 hours and after treatment.The two groups were observed with clinical symptoms and signs disappeared,the ECG changes and CK,CK-MB changes.Results Clinical signs and symptoms of treatment group disappeared soon,and serum CK,CK-MB returned to normal rate is high compared with the control group significantly.Conclusion Exogenous FDP has a certain therapeutic effect on moderate to severe HIE with myocardial damage,contributes to recovery of heart and brain function.
