Analysis of Prognosis Factors in 54 Patients with Acute Promyelocytic Leukemia
- VernacularTitle:急性早幼粒细胞白血病54例预后因素分析
- Author:
Hongfeng GE
;
Zhong YUAN
- Publication Type:Journal Article
- Keywords:
Acute promyelocytic leukemia;
Retrospective study;
Long-term survival;
Prognostic factors
- From:
Journal of Medical Research
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prognosis and its related factors of acute promyelocytic leukemia(APL).Methods Fifty-four patients with APL,from January 1994 to February 2005 in our hospital,were studied retrospectively.Univariate analysis of the potential factors influencing survival of these patients was carried out by comparison of the cases in same stage with chi square test and Log-Rank method.Prognostic indicators were demonstrated by CR rate,overall survival(OS)and event-free survival(EFS).Results 45 patients(83.3%)entered CR.The results showed that 1-year and 3-year OS of 54 patients were 81.5% and 73.3% respectively,1-year and 3-year EFS were 78.4% and 66.6% respectively.The estimated 5-year OS and EFS were 60.5?2.4% and 52.4?1.5% respectively.The analysis of prognostic factors showed that:Sex,age,initial WBC count,initial PLT count,marrow cellular morphology features,first induction regimen and time from induction therapy to CR were all important prognostic factors of APL.Conclusion Factors,including age
