Effect of Lactobacillus Plantarum on expression of tight-junctional molecules in rat hepatocytes during common bile duct ligation
- VernacularTitle:植物乳酸杆菌对阻塞性黄疸大鼠肝紧密连接蛋白表达的影响
- Author:
Ming ZHANG
;
Yukun ZHOU
;
Zhaoxin CHU
;
Huanlong QIN
- Publication Type:Journal Article
- Keywords:
Obstructive Jaundice;
Lactobacillus plantarum;
Tight junction;
Cell apoptosis
- From:
Parenteral & Enteral Nutrition
2004;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effects of oral Lactobacillus Plantarum supplementation on apoptosis of liver and tight junction of hepatocytes in an experimental model of obstructive jaundice.Methods: Wistar rats were randomly divided into five groups: sham-operated;bile duct ligation;bile duct ligation +LP(0.2 g/5 mL/day);bile internal drainage;bile internal drainage+LP.Hepatocyte apoptosis was quantitated using TUNEL assay.Transmission electron microscopy,RT-PCR and Western blot were used to observe tight junction associated proteins.Results: Compared to the sham-operated,a significant increase in apoptosis(P
