Influnce of wild chrysanthemum on some neuroendocrine factors in ventricular remodeling induced by abdominal aortic banding in rats
- VernacularTitle:野菊花对压力负荷性大鼠左室心肌及神经内分泌因子的影响
- Author:
Qi WU
;
Changxun CHEN
;
Weiliang GU
;
Jianping GAO
- Publication Type:Journal Article
- Keywords:
Wild chrysanthemum;
Ventrieular remodeling;
Renin-angiotensin-aldosterone system;
Hydroxyproline
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To approach the in unce of wild chrysanthemum on some neuroendoerine factors in ventricular remodeling induced by abdominal aortic banding(AAB)in rats.Methods:Myocardial hypertrophy,ventricular remodeling model was induced by abdominal aortic banding(AAB)in rats.After 35 days' treatment,the systolic blood pressure(SBP),diastolic blood pressure(DBP) and mean arterial pressure(MAP) were measured.Then the ratios of LVW/BW(1eft ventricle weight/ body weight),HW/BW(heart weight/body weight)were Calculated.The Angiotensin II(Ang II) content in heart tissue and the Aldosterone(ALD),Tumor Necrosis Factor(TNF-?)concentration of blood plasma were determined by radioimmunoassay.Results:The experimental data demonstrated that wild chrysanthemum could decrease SBP,DBP,MAP and the cardiac indexes of LVW/BW and HW/BW,significantly reduce the content of Ang II,ALD and TNF-?,decrease the Hydroxyproline content(P
