Study of nuclear proteomics for splenic lymphocytes of lupus mice affected by recipe of nourishing yin and clearing heat
- VernacularTitle:滋阴清热方对狼疮鼠脾淋巴细胞的核蛋白质的影响
- Author:
Wei WU
;
Ruiqiang FAN
;
Jiekai YU
;
Xian ZHANG
;
Guowei XUAN
;
Jianhong CHEN
- Publication Type:Journal Article
- Keywords:
Lupus;
Recipe of nourishing yin and clearing heat;
Nucleoprotein;
Splenic lymphocytes
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2006;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To probe e ect of a Chinese compound recipe of nourishing yin and clearing heat and prednisone on nuclear protein of splenic lymphocytes in mice.Methods:MRL/LPR female lupus mice were divided into four groups respectively treated with isotonic Na chloride,traditional Chinese medicine,Western medicine and integrated Chinese and Western medicine,then nucleoproteins of splenic lymphocytes were extracted and detected by SELDI-TOF-MS method.Result:There were some proteins in control group which aggravated autoimmune course,and some proteins in Western medicine group which rivalried immunological activity;integrated Chinese and Western medicine and Western medicine showed similarly e ect on nucleoprotein of splenic lymphocytes.Conclusion:The recipe of nourishing yin and clearing heat and prednisone can treat the disease by uencing in the di erentiation of splenic lymphocytes and the expression of proteins.
