Metabotropic glutamate receptors and related nervous diseases
- VernacularTitle:亲代谢型谷氨酸受体和相关神经疾病
- Author:
Rui LONG
;
Junrong DU
- Publication Type:Journal Article
- Keywords:
glutamic acid;
metabotropic glutamate receptors;
nervous diseases;
epilepsy;
parkinson′s disease;
ischemic cerebral apoplexy;
pain
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Excessive release of glutamic acid plays an important role in the occurring and development of many nervous system diseases.Ionotropic glutamate receptors antagonists are shown to have therapeutic effect in animal models,but their clinical application is limited by their effects of blocking the normal excitatory neurotransmission.However,metabotropic glutamate receptors can suppress the release of glutamic via presynaptic mechanisms,which makes them the new targeting points of certain nervous system disease.This paper reviews the recent research progress of mGluRs in nervous diseases both at home and abroad.
