Research of enalapril on rat myocardial fibrosis and its mechanism
- VernacularTitle:依那普利抗异丙肾上腺素诱导的心肌纤维化作用及机制
- Author:
Hongxia SUN
;
Shijie YANG
- Publication Type:Journal Article
- Keywords:
enalapril(Ena);
isoprenaline(Iso);
myocardial fibrosis(MF);
TGF-?1
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of enalapril(Ena) on cardiac fibrosis induced by isoprenaline(Iso) and to explore its mechanism.Methods Effect of Ena and captopril(Cap) on collagen content,HW/BW,LVI,hydroxyprolnie(Hyp) level,and TGF-?1 protein expression was observed with IH and WB in rats induced by Iso subcutaneous injection.Results Different doses of Ena could decrease HW/BW,LVI and Hyp level dramatically,and decrease TGF-?1 protein expression which was closely related to myocardial fibrosis(MF).Conclusion Enalapril can inhibit TGF-?1 protein expression,by which inhibit myocardial fibrosis.
