Effects of intracerebroventricular injection of bicuculline or NMDA on the amnestic effect induced by etomidate
- VernacularTitle:侧脑室注射荷包牡丹碱、NMDA对依托咪酯所致遗忘作用的影响
- Author:
Dan WANG
;
Tijun DAI
;
Tao MA
;
Jing MENG
- Publication Type:Journal Article
- Keywords:
etomidate;
receptor;
bicuculline;
NMDA;
mice;
amnestic;
step down test;
step through test
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the relationship between GABAA receptor or NMDA receptor and the amnestic effect induced by etomidate.Methods Amnestic model was established by intraperitoneal injection of etomidate(3 mg?kg-1) in mice before intracerebroventricular injection of different doses of bicuculline or NMDA,then the error times,step down latency and step through latency were observed and recorded in the step down test and step through test.Results Bicuculline(2,4 ?g) instead of NMDA by intracerebroventricular injection could decrease the error times and increase the step down latency and step through latency of amnestic mice in the step down test and step through test.Conclusion GABAA receptor rather than NMDA receptor may be an important target for the amnestic effect induced by etomidate.
