Pharmacoepigenetics and interindividual variations in drug response
- VernacularTitle:表观遗传药理学与药物反应个体差异
- Author:
Lan FAN
;
Guo WANG
;
Jianghua TU
;
Honghao ZHOU
- Publication Type:Journal Article
- Keywords:
pharmacoepigenetics;
interindividual variations in drug response;
pharmacokinetics;
DNA methylation;
microRNAs;
histone modification
- From:
Chinese Pharmacological Bulletin
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
With the development of pharmacogenetics and pharmacogenomics,pharmacoepigenetics potentially offers another level of explanation for interindividual variations in drug response that cannot be accounted for on the basis of genetic polymorphisms.Many genes encoding enzymes,drug transporters,transcription factors,drug targets,and nuclear receptors are under epigenetic control,which has implications in the context of interindividual variations in drug response as well as drug resistance during cancer treatment.In this overview,we summarize the newest advancement in this field.
