Effects of remote preconditioning on inflammatory cytokines and respiratory index of rabbit lung injured by ischemia-reperfusion
- VernacularTitle:远隔预处理对兔肺缺血再灌注后炎症细胞因子和呼吸指数的影响
- Author:
Jianwei WU
;
Zhilong GENG
;
Dong LIU
;
Hong CAO
;
Fang WU
- Publication Type:Journal Article
- Keywords:
reperfusion injury;
lung;
cytokines;
remote preconditioning
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of remote preconditioning on inflammatory cytokines and respiratory index of rabbit lung injured by ischemia/reperfusion.Methods Eighteen rabbits were randomly divided into three groups(6 each):control group(C),ischemia-reperfusion group(I/R)and remote preconditioning group(R).The plasma concentrations of interleukin-6(IL-6),tumor necrosis factor-?(TNF-?)and interleukin-10(IL-10)were measured before ischemia and 60,120 and 180 min after reperfusion.Respiratory index(A-aO2/PaO2)was calculated before ischemia and 15,30,60,120 and 180 min after reperfusion.The animals were sacrificed after reperfusion,and the left lung was removed for calculation of wet/dry(W/D)ratio and lung permeability index,histological examination was done with light microscope,and diffuse alveolar damage(DAD)scores was estimated.Results The plasma concentrations of IL-6 and TNF-? were significantly higher in I/R group than in C group(P
