Effect of estrogen receptor ? on the formation of mice endometriosis
- VernacularTitle:雌激素?受体对子宫内膜异位症形成的影响
- Author:
Zheng GUAN
;
Tingyu GONG
;
Qiang SUN
;
Yali LI
- Publication Type:Journal Article
- Keywords:
mice,knockout;
estrogen receptor beta;
endometriosis
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of estrogen receptor ?(ER-?)on the formation of mice endometriosis.Methods Endometriosis animal model was established with 30 ER-? knockout(?ERKO)mice and 22 ER-? non-knockout(?ER)mice.All the mice were divided into three groups:intact group(?ERKO 10 and ?ER 8),ovariectomy group(?ERKO 10 and ?ER 7)and ovariectomy + estradiol treatment group(?ERKO 10 and ?ER 7).The endometriotic grafts were taken out from all the mice 2 weeks after operation,and the weight,histological structure and the expression of MMP-9 in the grafts were analyzed and compared between ?ERKO and ?ER mice.Results The endometriotic grafts were significantly heavier 2 weeks after transplantation than that before transplantation in intact group(P0.05).In addition,no significant differences were found between the ?ERKO and the ?ER mice in endometriotic grafts' weight,the histopathologic structure and the expression of MMP-9.Conclusion ER-? may throw few influence on the formation of endometriosis.
