Effects of Rhein on resistin mRNA expression of adipose tissue and plasma free fatty acid in diabetic obese rats
- VernacularTitle:大黄酸对糖尿病肥胖大鼠脂肪组织抵抗素基因表达及血浆游离脂肪酸水平的影响
- Author:
Qingyang LIU
;
Shijia YU
- Publication Type:Journal Article
- Keywords:
Rhein;
Resistin;
Plasma free fatty acid(FFA);
Insulin resistance
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the mechanism of therapeutic effects of Rhein on insulin resistance from aspects of the expression of resistin mRNA and plasma free fatty acid(FFA) in diabetic obese rats.Methods:The streptozotocin(STZ) and high fat diet-induced diabetic obese rats were divided into three groups at random.They were differently treated with Rhein,pioglitazone and saline by gavage.The expressions of resistin mRNA,plasma free fatty acid(FFA),as well as blood lipid in all groups were detected after administration by gavage for 8 weeks.Results:Similar to pioglitazone,Rhein can reduce the expression of resistin mRNA and the level of FFA,TC,TG and LDL(P
