Effect of ginkgo leaf extract on oxidative stress and haemodynamics in diabetic nephropathy patients
- VernacularTitle:银杏叶提取物对糖尿病肾病抗氧化应激及血液流变作用的影响
- Author:
Lili ZHANG
;
Shuhua LIU
;
Fuliang WANG
;
Zhiming ZHAO
;
Hongmei MA
- Publication Type:Journal Article
- Keywords:
ginkgo leaf extract;
diabetic nephropathy;
oxidative stress;
hemorrheology
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the effect of ginkgo leaf extract on oxidative stress and haemodynamics of diabetic nephropathy(DN).METHODS:The patients of DN were divided into ginkgo leaf extract treatment group and control group.The changes of serum superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),malondialdehyde(MDA) and hemorheology indexes were observed.RESULTS:Before treatment,serum SOD,GSH-Px,MDA and hemorheology indexes had no significant difference between ginkgo leaf extract treatment group and control group.After treatment,the serum levels of T-SOD and GSH-Px were increased;the level of MDA,hemorheology indexes,erythrocyte aggregation index and platelet aggregation rate were decreased significantly in ginkgo leaf extract treatment group compared with those in control group(P
