Research on anticonvulsive and antiepileptic effect of alpha-asarone and its mechanism
- VernacularTitle:?-细辛脑的抗惊厥、抗癫痫作用及其机制研究
- Author:
Lin HAN
;
Daoquan TANG
;
Xiaoxing YIN
;
Yuanyuan GAO
;
Yaqin WEI
- Publication Type:Journal Article
- Keywords:
?-asarone;
anticonvulsion;
antiepileptic;
ATPase;
antioxidation;
amino acid
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study the anticonvulsive and antiepileptic mechanism of ?-asarone.Methods ?-asarone was intraperitoneally injected (ip) in mice and acute epileptic mouse models were made after 30 min.Change of ATPase,index of antioxidation,and variation of amino acid (AA) contents in brain of epileptic mice were used to investigate ?-asarone′s anticonvulsive and antiepileptic mechanism.Results For ?-asarone treated epileptic mice,when compared with model group,glutamate/gamma-aminobutyric acid (Glu/GABA) was greatly decreased (P
