The research progress of BAPTA-AM
- VernacularTitle:BAPTA-AM的研究现状
- Author:
Biwei SONG
;
Zhaoxing CHU
- Publication Type:Journal Article
- Keywords:
BAPTA-AM;
cell protection;
stroke;
calcium chelator;
apoptosis;
calcium overload
- From:
Chinese Pharmacological Bulletin
2003;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
BAPTA-AM is a standard tool agent of calcium chelating.After entering into cells,BAPTA-AM is metabolized by lipase and forms BAPTA.The latter combines with calcium ion rapidly and high selectivity.The effects of BAPTA-AM can effectively protect nerve cells against hypoxic/ischemic injury and protect hepatocytes against cytotoxins attack.BAPTA-AM is a hopeful candidate for treating stroke,liver failure and other clinical critical diseases.
