Effects of liver X receptor agonist on the expressions of C-reactive protein and CD40 ligand and contents of smooth muscle cells in the aorta of ApoE gene knockout mice
- VernacularTitle:肝X受体激动剂对ApoE基因敲除小鼠主动脉壁C-反应蛋白和CD40配体表达及平滑肌细胞含量的影响
- Author:
Jun CHENG
;
Jinping LI
;
Zhuo TIAN
;
Houyuan HU
- Publication Type:Journal Article
- Keywords:
liver X receptor;
ApoE gene knockout mice;
C-reactive protein;
CD40 ligand;
smooth muscle cell;
inflammation
- From:Journal of Third Military Medical University
2003;0(13):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of liver X receptor agonist on the expressions of C-reactive protein and CD40 ligand and smooth muscle cell ?-actin in the aorta of ApoE gene knockout mice with earlier atherosclerosis. Methods Male ApoE gene knockout mice (8-week old) were divided randomly into control group and T0901317 treatment group (n=6 in each group). The mice in T0901317 group were administered intraperitoneally with T0901317 at the dose of 20 mg?kg-1?d-1 for 4 weeks. Mice in the control group were only given equivalent amount of dimethyl sulfoxide (DMSO). The expressions of C-reactive protein and CD40 ligand and smooth muscle cell ?-actin were detected by immunological histochemical method. Results The expressions of C-reactive protein and CD40 ligand in the atherosclerotic plaque in the aortic wall were significantly lower in T0901317 group as compared with those in the DMSO control group (P0.05). Conclusion Liver X receptor agonist may reduce the formation of atherosclerotic lesions by inhibiting the inflammation and the expressions of C-reactive protein and CD40 ligand in the aorta of ApoE gene knockout mice.
