Effect of Low Molecular Weight Agarieus Blazei Murill Polysach-aride on Colon Carcinoma HT-29 Cell-endothelium migration and Adhesion
- VernacularTitle:低分子量姬松茸多糖对HT-29细胞与内皮细胞迁移、黏附的影响
- Author:
Chun ZHANG
;
Wei SUI
;
Huirong WANG
;
Xueyan LI
;
Jicheng LIU
- Publication Type:Journal Article
- Keywords:
Low molecular weight polysaccharide;
Adhesion;
Metastasis;
Transmigration
- From:
Journal of Medical Research
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of low molecular weight polysaccharide lsolated from agaricus blazei murill (LMPAB) on adhesion and migration of tumor cell and HUVECs. Methods HT-29 cell and HUVECs proliferation was analyzed by MTT.Adhesion and transmigration monolayer HUVECs ability of HT-29 was examined by spectrophotometry and transwell chambers.Results LMPAB showed no cytotoxic effect on HT-29 cells and HUVECs. LMPAB could significantly decrease HT-29 adhesion and transmigration through HUVECs.Conclusion LMPAB exerts the anti-tumor metastasis activity via inhibition of tumor cell adhesion and migration HUVECs.
