Effects of Different Doses of Sufentanil on Hemodynamic Response to Anesthesia Induction in Patients with Hypertension Undergoing Coronary Artery Bypass Graft
- VernacularTitle:舒芬太尼对合并高血压冠状动脉旁路移植术患者麻醉诱导时血流动力学影响
- Author:
Juzhao ZHAO
;
Hongwu WANG
;
Yuliang XUE
- Publication Type:Journal Article
- Keywords:
Sufentanil;
Hypertension;
Coronary artery disease;
Intubation intratracheal;
Hemodynamic phenomena
- From:
Journal of Medical Research
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the effects of different doses of sufentanil on hemodynamic response to anesthesia induction in patients with hypertension undergoing coronary artery bypass graft (CABG). Methods 45 ASAⅡor Ⅲ patients aged 46~65years old and weighing 58~79kg scheduled for elective undergoing CABG surgery under general anesthesia requiring tracheal intubation were randomly divided into 3 groups(n=15 each)according to different doses of sufentanil. The patients were premedicated with intravenous scopolamine 0.005mg/kg and midazolam 0.05mg/kg. Anesthesia was induced with etomidate 0.3mg/kg and rocuronium 0.6 mg/kg and then received 1.0?g/kg(group S1) or 1.2?g/kg (group S2) or 1.5?g/kg (group S3) of sufentanil injected intravenously slow-moving at 3 min before orotracheal intubation. ECG,HR,BIS,BP and SpO2 were monitored and recorded before induction of anesthesia(the baseline values T0),and after induction of anesthesia and before intratracheal intubation instantly (T1),1 min(T2),5 min (T3)and 10 min (T4) after intratracheal intubation.Results There were no significant differences between 3 groups with respect to age,sex,body weight and hypertension class. Hemodynamic variables were significantly changes at 3 groups at T1-4 than T0(P
