Effects of Estradiol on the Chronic Periodontitis in Experimental Rat
- VernacularTitle:雌二醇水平降低加速大鼠实验性牙周炎的发展
- Author:
Jianhua ZHU
;
Libo KU
;
Guoquan XU
- Publication Type:Journal Article
- Keywords:
Periodontitis;
Animal model;
Matrix metalloproteinases;
Immunohistochemistry
- From:
Journal of Medical Research
2006;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective In this research,the relationship between blood estrogen level and periodontitis in rats was studied. Methods Twenty-four female Wister rats were randomly divided into three groups:control group,sham operation group and ovariectomized group. Rat chronic periodontitis model was established by ligating the rat's second molar with a steel wire in the sham operation group and ovariectomized group. Serum estrogen level of the rats was detected respectively. Dental X-ray observation,histological examination and immunohistochemistry were employed for the characterization of rat's chronic periodontitis. Results Compared with both control group and sham operation group,a significant decrease in scrum estrogen level was observed in ovariectomized group (P
