Combined effects of rhBMP-2 and rhVEGF coated onto implants on osseointegration: pilot study.
10.4047/jkap.2013.51.2.82
- Author:
Jung Bo HUH
1
;
Mi Jung YUN
;
Chang Mo JEONG
;
Sang Wan SHIN
;
Young Chan JEON
Author Information
1. Department of Prosthodontics, School of Dentistry, Pusan National University, Yangsan, Korea. jeonyc@paran.com
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
rhBMP-2;
rhVEGF;
Implant stability quotient;
Removal torque;
Osseointegration
- MeSH:
Animals;
Bone Morphogenetic Protein 2;
Humans;
New Zealand;
Osseointegration;
Pilot Projects;
Tibia;
Torque;
Vascular Endothelial Growth Factor A
- From:The Journal of Korean Academy of Prosthodontics
2013;51(2):82-89
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The present study is aimed to evaluate the combined effect of recombinant human bone morphogenetic protein 2 (rhBMP-2) and recombinant human vascular endothelial growth factor (rhVEGF) coated onto anodized implants on osseointeration. MATERIALS AND METHODS: Six New Zealand white rabbit were used in this study. Each animal received 4 implants that were either coated with rhBMP-2 and rhVEGF (Study group) or anodized implant (Control group) in both tibia. This was performed using a randomized split-mouth design. A total 24 implants were used. The implant stability quotient (ISQ) value using resonance frequency analyser and removal torque (RTQ) measurement were investigated at 2 and 8 weeks. The t-test was used for statistical analysis (alpha=.05). RESULTS: Control and study group showed good osseointegration at 8 weeks. The ISQ and RTQ values of study group were significant compared with the control group at 8 weeks (P<.05). However, No statistical significance was observed at 2 weeks (P>.05). CONCLUSION: It was concluded that rhBMP-2 with rhVEGF coated onto anodized implants can induce better osseointegration at late healing period.
