Antiinflammatory protective mechanism of HuoXueTongMaiLing on experimental rats with myocardial ischem
- VernacularTitle:活血通脉灵对实验性心肌缺血大鼠心肌损伤的抗炎保护作用
- Author:
Jixiang FAN
;
Shaofang GAO
;
Na LIU
- Publication Type:Journal Article
- Keywords:
HXTML;
Myocardial ischemia;
Coronary heart disease;
Isoproterenol;
Inflammatory factor
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objectie:To study the protective effects and mechanism of Huoxuetongmailing(HXTML) on experimental myocardial ischemic rats by zhuodu.Methods 50 healthy male Wister rats were randomly divided into groups namely blank group,model group,Cedocard group,HXTMLmax and HXTMLmin group,10 rats in each group.Each rat had been recordⅡelectroca rdiographic(ECG) before the experiment.Hyperlipemic forage was feeded and ISO was subcutaneously injected into rats except Blank group to cause myocardial ischemia.Blank group and model group,respectively,the volume of normal saline irrigation,etc.,and the rest of the group were irrigated isosorbide dinitrate,HXTMLmax and HXTMLmin dose treatment.After treatment,the myocardium zymogram(CK,CK-MB and LDH) and inflammatory factor were detected by modern medical method.Results:HXTMLmax and HXTMLmin dose could signifi cantly reduce the levels of serum enzymes(P
