Expression of Id3,VEGF and C-erbB-2 and clinical significance in patients with breast cancer
- VernacularTitle:Id3、VEGF、C-erbB-2在乳腺癌中的表达及临床意义
- Author:
Decai ZHANG
;
Jinghua ZHANG
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
ID3 protein, human;
vascular endothelial growth factor A;
receptor, erbB-2;
breast neoplasms;
immunohistochemistry
- From:
Medical Journal of Chinese People's Liberation Army
2001;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between clinicopathological parameters and the expressions of inhibitor of differentiation/DNA binding 3 (Id3), vascular endothelial growth factor (VEGF) and human epidermal growth factor receptor-2 (HER-2/C-erbB-2) in patients with breast cancer. Methods The protein expressions of Id3, VEGF and C-erbB-2 were detected by SABC immunohistochemistry in 70 spceimens of breast cancer, 40 specimens of tissue adjacent to breast cancer, 20 specimens of fibroadenoma and 20 specimens of normal breast tissue. Results The expressions of Id3, VEGF and C-erbB-2 in breast cancer tissue (88.6%, 95.7% and 20.0%, respectively) were significantly higher than that in the other tissues (P0.05), while the expression of C-erbB-2 protein substantially varied among the patients of breast cancer in different pTNM stages (P
