THE CHANGES OF COX-2 AND APOPTOSIS GENE EXPRESSION IN THE INHIBITION EFFECT OF DOCOSAHEXAENOIC ACID ON HUMAN PANCREATIC CANCER CELL IN VITRO
- VernacularTitle:COX-2及凋亡基因表达在二十二碳六烯酸抑制人胰腺癌细胞体外增殖中的变化
- Author:
Wei QIN
;
Shengtao ZHU
- Publication Type:Journal Article
- Keywords:
DHA;
pancreatic cancer;
COX-2;
Bcl-2;
Bax
- From:
Acta Nutrimenta Sinica
1956;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of COX-2 and apoptosis gene Bcl-2,Bax expression in the inhibition effect of DHA on pancreatic cancer cell lin(ePatu8988)in vitro and investigate the mechanism. Method The inhibition of cell proliferation was evaluated by MTT assay. Cell apoptosis induction and COX-2, Bcl-2, Bax expression were evaluated by flowcytometry. Results DHA could inhabit the proliferation of pancreatic cell and induce cell apoptosis, both of which were time-dependent and dose-dependent(P
