Advancement on the therapy of somatostatin on liver fibrosis
- VernacularTitle:生长抑素治疗肝纤维化研究进展
- Author:
Xiaobing XU
;
Miaofang YANG
;
Renmin ZHU
- Publication Type:Journal Article
- Keywords:
somatostatin;
hepatic stellate cell;
hepatic fibrosis;
liver cirrhosis;
schistosoma mansoni
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2002;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Somatostatin,a cyclopeptide hormone,is generally distributed in vivo.Some studies have indicated that somatostatin can reduce proinflammatory cytokine in hepatic stellate cells and extracellular matrix,and inhibit their proliferation and contraction,promote their apoptosis.It can also regulate the function of Kupffer cells,influence the homing of hepatic stem cells.Somatostain has therapeutic effect on liver fibrosis,especially on the liver fibrosis caused by schistosoma mansoni.
