Role of protease activated receptor-2 in rheumatoid arthritis:recent progress
- VernacularTitle:蛋白酶激活受体2在类风湿关节炎中的作用研究进展
- Author:
Suiyi LIU
;
Qingsong YANG
;
Yixin JIA
;
Shengming DAI
- Publication Type:Journal Article
- Keywords:
protease activated receptor-2;
rheumatoid arthritis;
mast cells;
tryptases
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Protease activated receptor-2(PAR-2)is a G-protein-coupled receptor.Recent studies indicate that PAR-2 is mainly expressed in leukocytes and activated by pancreatin and(or)tryptase,which subsequently induces inflammation through degranulation of leukocytes.Activation of PAR-2 in leukocytes is possibly involved in the pathogenesis of rheumatoid arthritis.
