Relationship between RUNX3 expression and precancerous gastric lesions in high-risk population
- VernacularTitle:胃癌高发区人群RUNX3表达与胃黏膜病变的关系
- Author:
Wenqing LI
;
Kaifeng PAN
;
Yang ZHANG
;
Lian ZHANG
;
Junling MA
;
Tong ZHOU
;
Jiyou LI
;
Zheng WANG
;
Ying SU
;
Weicheng YOU
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Gastric mucosa;
Core binding factor alpha 3 subunit;
Helicobacter infections
- From:
Journal of Peking University(Health Sciences)
2004;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the association between RUNX3 expression and Helicobacter pylori(H.pylori)-associated precancerous gastric lesions.Methods: A population-based study was conducted in Linqu County,Shandong Province,a high-risk area of gastric cancer in China.RUNX3 expression was determined by immunohistochemistry analysis in 1 026 H.pylori infected subjects with different gastric lesions.Results: Among 1 026 subjects,359(35.0%,359/1 026) was positive.The prevalence rates of RUNX3 expression decreased steadily with severity of gastric lesions,65.6%(40/61) among those with superficial gastritis /normal(SG/N),and 22.4%(60/268) among those with dysplasia(DYS)(P
