Influence of Chinese Herbs for Activating Blood Stasis on The Endothelial Cells in Poresky's PCOS Rats
- VernacularTitle:活血化瘀方药对Poresky大鼠模型内皮细胞的影响
- Author:
Pingping CAI
;
Yuzhen ZHANG
- Publication Type:Journal Article
- Keywords:
PCOS;
animal model;
activating blood stasis;
endothelial cell
- From:
Journal of Zhejiang Chinese Medical University
2006;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To observe the effect of Chinese herbs for activating blood stasis on the shape and function of the endothelial cells in rat aorta.[Method]Rat models of PCOS have been established according to Poresky,randomized into animal model and Chinese medicine group(TCM group),normal rats were control group.Measure the serum level of FSH,LH,T,INS and plasma ET PAI-1,and observe the endothelial cell morph.[Results] In the model group,the endothelia cells of the aorta were contracted,with discontinuous basement membrane,inflated chondriosome,the middle layer smooth muscles tending to move inside and out of the normal shape of intraendothelial junction.In the TCM group,the endothelial cells appeared flat,arranging along the long axis of the blood vessels,normal endothelial cell integrity with scanty cytoplasm and the microscopic appearance shows highly developed golgiosome rough endoplasmic reticulum and smooth endoplasmic reticulum.The model group had a more increased serum level of PAI-I and ET than those of the control group,and showed the significant difference(P0.05).The TCM group had more decreased level of ET than those of the normal group(P
