Effect of long-term blood purification on homocysteine level and atherosclerosis in maintenance hemodialysis patients
- VernacularTitle:血液净化治疗对尿毒症患者同型半胱氨酸水平以及动脉粥样硬化程度的影响
- Author:
Ling LIU
;
Ling ZHONG
;
Liping FENG
;
Ling ZHANG
- Publication Type:Journal Article
- Keywords:
blood purification;
atherosclerosis;
homocysteine;
treatment
- From:Journal of Third Military Medical University
2003;0(11):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of long-term blood purification on atherosclerosis(AS) in maintenance hemodialysis(MHD) patients by measuring serum levels of homocysteine(Hcy) and carotid artery intima-medial thickness(IMT).Methods Seventy-two MHD patients visiting our hospital from June 2006 to December 2007,according to their blood purification mode,were assigned to three groups: hemodialysis(HD,n=25),hemodialysis+hemodiafiltration(HD+HDF,n=30),hemodialysis+continuous renal replacement therapy(HD+CRRT,n=17).Another 25 healthy subjects served as controls.Serum Hcy was detected before and after one-year treatment and meanwhile color Doppler ultrasonography was performed to check IMT of carotid artery and atheromatous plaques.Results The serum levels of Hcy,IL-6,MCP-1,hs-CRP in MHD patients were significantly higher than those in healthy controls(P
