Clinical Study of the Effect and Side-effects in Patients with Multiple Myeloma by the Treatment of T-VAD
- VernacularTitle:T-VAD方案治疗多发性骨髓瘤临床研究
- Author:
Qilin ZHAN
;
Meiqi DIN
;
Jun LI
;
Long ZHU
- Publication Type:Journal Article
- Keywords:
Thalidomide;
Multiple myeloma;
VAD regimen
- From:
Journal of Medical Research
2006;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect and side-effect in patients with multiple myeloma by the treatment of T-VAD.Methods To observe the effect and side-effect in 23 newly diagnosed patients with the treatment of T-VAD,and analyze them.Results Out of 23 patients,9(39%)patients gained complete remission(CR)and 11(49%)achieved partial remission(PR).The median survival time was 46 months.The side-effects consisted of fatigue(100%),somnolence(78%),constipation(69%),infection(48%),secondary diabetes mellitus(30%),numbness(17%),leukopenia(22%)and no one patient experienced deep vein thrombosis(DVT).Disease free survival of three years was 50%.Conclusion The treatment 0f T-VAD on patients with MM is an effective regimen,though there are many side-effcts,such as infection,they are relatively well-tolerated.
