Relationship between the expression of Ezrin and proliferation and metastasis of hepatocellular carcinoma
- VernacularTitle:埃兹蛋白表达与肝细胞癌增殖及转移的关系研究
- Author:
Peng SHEN
;
Ning SU
;
Bin CHEN
;
Dayong ZHENG
;
Rongcheng LUO
- Publication Type:Journal Article
- Keywords:
carcinoma,hepatocellular;
ezrin;
cadherins;
proliferating cell nuclear antigen
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of Ezrin in hepatocellular carcinoma(HCC),and the relation of Ezrin expression to E-cadherin,proliferating cell nuclear antigen(PCNA) and clinical features of HCC.Methods Forty-nine cases of HCC were divided into high and low invasive groups according to tumor size,disseminated lesions,distant metastasis,tumor capsule and portal vein tumor thrombus.The expression of Ezrin,E-cadherin and PCNA in normal liver tissues,HCC and adjacent tissues were determined by immunohistochemistry,and the relation of the expression to clinical features was analyzed.Results The Ezrin expression was found in normal liver tissues,HCC and adjacent tissues,and was significantly higher in HCC tissues than in adjacent and normal liver tissues(P
