Analysis of lung function of patients with leukemia before and after transplantation of stem cells
- VernacularTitle:白血病患者干细胞移植前后肺功能变化分析
- Author:
Yi ZHOU
;
Weiguo ZHAO
;
Lihui LIU
;
Yu LIU
- Publication Type:Journal Article
- Keywords:
respiratory function tests;
leukemia;
hematopoietic stem cell transplantation
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes in pulmonary function of patients with leukemia before and after stem cells transplantation(SCT).Methods Twenty-three patients with leukemia were assigned to group A,while 35 healthy controls to group C.All spirometric values were recorded including percentage predicted forced vital capacity(FVC),residual volume(RV),total lung capacity(TLC),forced expiratory volume in one second(FEV1),maximal expiratory flow in 50% and 75% vital capacity(MEF50%,MEF75%),diffusing capacity of the lung for carbon monoxide(DLCO),and ratio of carbon monoxide diffusion capacity to alveolar ventilation(DLCO/VA).Twenty patients with leukemia undergone stem cell transplantation were assigned to group B.Changes in lung function 7 days before and 3-12 months after transplantation were recorded.Group B was sub-grouped according to the source of stem cells and extent of anemia.Changes in lung function and infection were observed subsequently.Results Patients in group A experienced a significant decrease in predicted percentage of DLCO,DLCO/VA and MEF75%(76.25%?22.48%,83.77%?21.32% and 61.13%?19.08%,respectively),which were significantly different compared with that in group C(118.21%?19.34%,112.4%?20.96% and 81.02%?12.10%,P
