Effect of Diammonium Glycyrrhizinate Injection on bronchus,lung tissue and amount of eosinophils(EOS)in rats with asthma
- VernacularTitle:甘利欣注射液对哮喘大鼠支气管和肺组织形态及嗜酸粒细胞数的影响
- Author:
Zhen WANG
;
Junchao YANG
;
Wanru CAI
;
Xinhua WANG
;
Yuefang YU
- Publication Type:Journal Article
- Keywords:
Asthma;
Diammonium glycyrrhizinate;
Animal;
Eosinophils
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of diammonium glycyrrhizinate injection on bronchus,lung tissue and amount of eosinophils(EOS)in rats with asthma and to discuss the mechanism of diammonium glycyrrhizinate intervention on airway inflammation in asthma.Methods:To divide 60 male SD rats into 6 groups as following:normal control group,model group,dexameth group,high dose of diammonium glycyrrhizinate group,middle dose of diammonium glycyrrhizinate group and low dose of diammonium glycyrrhizinate group(n=10).After setting up the model of rats with asthma,we detect the EOS in both rats'blood serum and bronchoalveolar lavage and observe the pathological change in bronchus and lung tissue in rats of each group.Results:Not only the amount of EOS of rats in model group is bigger than that in normal control group(P
