The expression and its clinical significance of granulocyte colony-stimulating factor receptor in acute myelocytic leukemia
- VernacularTitle:粒细胞集落刺激因子受体在急性髓性白血病骨髓CD34~+细胞中的表达及其临床意义研究
- Author:
Lin FU
;
Zonghong SHAO
;
Rong FU
;
Yong LIANG
;
Wen ZHAI
;
Guojin WANG
;
Huaquan WANG
;
Limin XING
;
Yuhong WU
;
Hong LIU
;
Jia SONG
;
Jing GUAN
;
Jun WANG
;
Lijuan LI
;
Yue REN
;
Hui LIU
;
Xiaoming WANG
;
Erbao RUAN
- Publication Type:Journal Article
- Keywords:
acute myeloid leukemia;
granulocyte colony-stimulating factor;
granulocyte colony-stimulating factor receptor
- From:
Chinese Journal of Practical Internal Medicine
2001;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of granulocyte colony-stimulating factor receptor(G-CSFR,CD114)in acute myelocytic leukemia(AML)bone marrow CD34+cells and evaluate G-CSF's secutiy of applying to the patients of AML after chemotherapy.Methods From March 2008 to January 2009,62 AML patients[33 deno-vo or relapsed AML patients,29 AML patients in complete remission(CR)]and 16 normal controls in the General Hospital,Tianjin Medical University were detected for the expression of G-CSFR in CD34+cells by Fluorescence-activated cell sorer(FCM)and Semi-quantitative reverse transcription-polymerase chain reaction(RT-PCR).Results The ratio of CD114+CD34+/CD34+ in the deno-vo or relapsed group,CR group and the control group were(11.69?2.91)%,(31.84?8.62)%,(32.87?8.44)% respectively(P0.05),G-CSFR mRNA expression in BMNNCs of the deno-vo or relapsed group,CR group and the control group were(30.52?6.21)%,(85.13?21.25)%,(91.57?18.64)% respectively(P0.05).13 AML patients were followed up.The ratio of CD114+CD34+/CD34+ before treatment and in CR were(12.58?2.00)% and (30.13?7.09)% respectively.The ratio before treatment was lower than that in CR(P
