Progress in studies on senescence accelerated mouse prone 8(SAMP8)
- VernacularTitle:快速老化小鼠SAMP8研究进展
- Author:
Weiqin ZHOU
;
Minggang BI
;
Guanhua DU
- Publication Type:Journal Article
- Keywords:
senescence accelerated mouse prone 8;
Alzheimer′s disease;
animal model
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The senescence accelerated mouse prone 8 strain was developed through phenotypic selection from a common genetic pool of AKR/J strain of mice.The SAMP8 strain exhibits age-related deterioration in memory and learning as well as A? accumulation early in its lifespan,and it is considered as an effective model for studying Alzheimer′s disease(AD).The SAMR1 strain(senescence accelerated resistant) is control,which exhibits normal aging characteristics.The present studies of SAMP8 have focused on revealing mechanism of accelerated deficits in learning and memory,and evaluating the efficiency of therapeutic drugs against AD.
