Establishment of the diarrhea-predominant IBS SD rat model and appraisal of its sensitivity
- VernacularTitle:腹泻型肠易激综合征大鼠模型的建立及敏感性评估的实验研究
- Author:
Hongmei TANG
;
Detang LI
;
Yinghua HUANG
;
Xue YAN
- Publication Type:Journal Article
- Keywords:
diarrhea-predominant;
IBS;
SD rat model;
intestinal tract sensitivity
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To establish diarrhea-predominant IBS SD rat model and appraise its intestinal tract.Method The postnatal rat of 8~21 days were given the successive stimulation of the inflammation inside the colon(rectum abouchement 0.087 mol?L-1 acetic acid 0.5 ml)to replicate the animal model of the IBS visceral hypersensitive.The change of IBS SD rat model organ sensitivity was studied,and the change of threshold of pain at ectocolon of model rat was observed,as well as the influence of excised intestinal canal systaltic motion with convulsion-induced agent for model rat.Results Model group was obviously lower than normal group with pressure threshold value of raise abdomen and extrados in the eighth week and the sixth week(P
