Effects of progesterone on morphine-induced conditioned place preference and levels of ?-receptor in hippocampus and striatum
- VernacularTitle:孕酮对吗啡精神依赖大鼠海马和纹状体中阿片受体水平的影响
- Author:
Dongzhen YU
;
Yanning HOU
- Publication Type:Journal Article
- Keywords:
progesterone;
morphine;
conditioned place preference;
?-receptor
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effects of progesterone on morphine rewarding effect and levels of ?-receptor in hippocampus and striatum.Methods 32 male SD rats were designated to 4 groups randomly with 8 in each,including blank control group,morphine group,progesterone group and progesterone plus morphine group.Conditioned place preference(CPP) test was used to investigate the morphine rewarding effect,and immunohistochemistry was established to determine the levels of ?-receptor in hippocampus and striatum.Results Compared with those of blank control group,5 mg?kg-1 morphine successfully induced the formation of CPP(P
