Association of TNF-A-863 and CGRP979 gene polymorphisms with susceptibility to severe chronic periodontitis in Chinese Han nationality
- VernacularTitle:TNF-A-863和CGRP基因多态性与中国汉族人重度慢性牙周炎易感性的关系
- Author:
Lingmin LI
;
Zhizhong CAO
- Publication Type:Journal Article
- Keywords:
severe chronic periodontitis;
tumour necrosis factor A-863;
calcitonin gene-related peptide;
gene polymorphisms
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship of TNF-A-863 and CGRP979 gene polymorphisms with the susceptibility to severe chronic periodontitis in Chinese.Methods:Buccal swabs were collected from 100 adult patients with severe chronic periodontitis and 118 healthy adult controls.DNA was extracted from each subjects of the two groups.PCR-LDR technique was used to identify the genotypes of TNF-A-863 and CGRP979.The difference in the genotypes between the two groups was analyzed by statistics software.Results:The genotype of TNF-A-863 was mainly TNF-A-863 A/C in patients with severe chronic periodontitis and TNF-A-863 C/C in healthy controls.There were significant differences in TNF-A-863 distribution between the two groups(P
