Expression and significance of peripheral CXCL9 and CXCR3 in rats with acute renal allografts rejection
- VernacularTitle:外周血CXCL9和CXCR3在大鼠肾移植急性排斥反应的表达及意义
- Author:
Jiabing LI
;
Yunfeng HE
;
Kang XIA
;
Xiaohou WU
- Publication Type:Journal Article
- Keywords:
renal transplantation;
acute rejection;
chemokines;
chemokine receptor
- From:Journal of Third Military Medical University
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate dynamic changes of chemokine CXCL9 and chemokine receptor CXCR3 to predict the early acute rejection in rats after renal transplantation. MethodsRenal allogeneic grafting was performed on Brown Norway or Lewis rats as donors and Lewis rats as recipients. CXCL9 in serum was measured by ELISA and CXCR3 mRNA in peripheral blood lymphocytes by RT-PCR at the time points of just before and 1, 3, 5, and 7 d after operation. Serum creatinine (Cr) was measured simultaneously. ResultsThe serum contents of CXCL9 and Cr, and CXCR3 mRNA level in allograft group were significantly higher than those in isograft group (P
