Erythropoietin improves proliferation but not differentiation of neural stem cells in vascular dementia rats
- VernacularTitle:促红细胞生成素对血管性痴呆大鼠神经干细胞增殖分化的影响
- Author:
Yan HUANG
;
Jingzhou WANG
;
Tao ZHANG
;
Yuejia LUO
- Publication Type:Journal Article
- Keywords:
vascular dementia;
neural stem cell;
erythropoietin;
rats
- From:Journal of Third Military Medical University
2003;0(09):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of erythropoietin (EPO) on the proliferation and differentiation of neural stem cells and on the cognition function of vascular dementia (VD) rats. MethodsTotally 45 Sprague-Dawlev (SD) rats were randomly and equally divided into the sham control group, the VD group, and the treatment group. The VD rat model was established by performing cerebral ischemia/reperfusion repeatedly and given an intraperitoneal injection sodium nitroprusside. The rats from the treatment group received an introperitoneal injection of EPO after the establish of VD model, and the animals from the others were treated with normal saline. The learning-memory abilities were measured by using computerized shuttle-training case and the proliferation and differentiation of neural stem cells were detected by immunofluorescence staining. ResultsThe active avoidance reaction (AAR) ratio in the VD group was significantly decreased compared with the sham control group (P
