The Effect of Kakkonein on the Expression of NF-?B after Hepatic Ischemia Reperfusion Injury
- VernacularTitle:葛根素对大鼠肝脏缺血再灌注损伤后NF-?B表达的影响
- Author:
Guangqiang LUO
- Publication Type:Journal Article
- Keywords:
Kakkonein;
Ischemia reperfusion;
Liver;
NF-?B
- From:
Journal of Medical Research
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of kakkonein on the expression of NF-?B after hepatic ischemia reperfusion injury in rats.Methods Male Sprague-Dawley rats were randomly divided into three groups:pseudo-operation normal control group,hepatic ischemia reperfusion injury model group,kakkonein group.After hepatic ischemia and reperfusion,we analyzed the expression of NF-?B by the methods of Western blot and RT-PCR.Results After hepatic ischemia reperfusion,the NF-?B level increased obviously comparing with the normal group.Comparing to the hepatic ischemia reperfusion injury model group,the NF-?B level decreased after treated with kakkonein.Conclusion The apigenin has a prominent protective effect on hepatic ischemia reperfusion injury in rats through regulating the expression of NF-?B.
