The Influence of Re Bi Ganule on Synovial Cell Apoptosis and T Cll Suets to AA Rats
- VernacularTitle:热痹颗粒对佐剂性关节炎大鼠滑膜细胞凋亡及T细胞亚群的影响
- Author:
Yong WANG
;
Min ZHANG
;
Weiwei JIN
;
Aiping HU
;
Yingqian ZHAO
- Publication Type:Journal Article
- Keywords:
Re Bi granule;
Rheumatoid arthritis;
Beriberoid pyretic arthralgia;
Mechanism
- From:
Journal of Medical Research
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mechanisms of Re Bi granule on treating RA.Methods Make SD maleness rats Adjuvant-Induced Arthritis(AA)which was derived by Freund's complete adjuvant(CFA)as investigation object.Make Wang Bi granule as positive control medicine,and divide it into six groups(blank group,model group,control group,Infusion of Re Bi granule high dose group and midst dose group and low dose group).Observe Re Bi granule's influence and mechanism to synovial cell apoptosis and T cell subsets.Results Re Bi granule could distinctly heighten synovial cell apoptosis ratio of AA rats,heighten CD8+cell's number and reduce CD4+cell's number,lower CD4+/CD8+ ratio,adjust T cells for two-way.Conclusion Re Bi granule not only is an effective treatment way for rheumatoid arthritis,but also can improve the abnormal immune status.
