Clinical Significance of Detection of Granulocyte Macrophage Colony Stimulating Factor,C Reaction Protein and Tumor Necrosis Factor-?lpha in Infant Cytomegalovirus Hepatitis
- VernacularTitle:婴儿巨细胞病毒性肝炎GM-CSF、CRP和TNF?检测的临床意义
- Author:
Guanglan ZHANG
;
Xidong WANG
;
Guihua HOU
- Publication Type:Journal Article
- Keywords:
Infant;
Hepatitis;
Cytomegalovirus;
Granulocyte macrophage colony stimul-ating factor;
C reaction protein;
Tumor necrosis factor-?lpha
- From:
Journal of Medical Research
2006;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of granulocyte macrophage colonystimulating factor(GM-CSF),C reaction protein(CRP)and tumor necrosis factor-?lpha(TNF?)in infant cytomegalovirus hepatitis.Methods Cytomegalovirus DNA of 56 cases of children with cytomegalovirus hepatitis and 51 normal controls in blood were detected using FQ-PCR.The levels of GM-CSF and TNF?in serum were assayed with ELISA,and CRP was measured with immunoturbidmemetry assay.Results The levels of M-CSF,CRP and TNF? in serum of infant cytomegalovirus hepatitis were higher obviously than those in serum of the normal control group.Conclution M-CSF,CRP and TNF? participate in pathological immune response and anti-infective immunity of cytomegalovirus hepatitis.
