The correlation between intestinal mucosa injuries and inflammatory reaction in cancer cachexia mice
- VernacularTitle:癌性营养不良小鼠肠黏膜损伤与炎症反应相关性研究
- Author:
Yunhe JIA
;
Zhiwei JIANG
;
Ning LI
;
Jiesho LI
- Publication Type:Journal Article
- Keywords:
Cancer cachexia;
Intestinal mucosa;
Cytokine
- From:
Parenteral & Enteral Nutrition
1997;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the correlation between intestinal mucosa injuries and inflammatory reaction in cancer cachexia mice. Methods: 14 male BALB/c mice were randomized into two groups: control group and tumor-bearing group.For tumor-bearing group,a suspension of 10 6 murine colon 26 adenocarcinoma cells was inoculated s.c into each mouse.Non-tumor body weight,intestinal villus height,width,basal layer thickness and muscular layer thickness,TNF-?,IL-1,IL-6,IL-10,IFN-?,sTNF-RⅠand sTNF-RⅡ in the serum and intestinal tissue were determined at the 16th day following the inoculation. Results: The non-tumor body weight and intestinal villus height and basal layer width in tumor-bearing group were lost significantly as compared with control group.The concentration of serum TNF-?,IL-6,sTNF-RⅠwere higher and the level of serum IL-10 was less in tumor-bearing group.The concentration of intestinal tissue TNF-? was higher but the IL-1,IFN-?,sTNF-RⅠ and sTNF-RⅡ were less in the tumor-bearing group. Conclusion: The intestinal mucosa injuries have close relation with the inflammatory reactions in cancer cachexia.
