Cell function changes of bone tissue in early glucocorticoid-induced femoral head necrosis and the therapeutic effects of external application of Chinese medicines
- VernacularTitle:兔激素性股骨头坏死早期骨组织细胞功能改变及外敷中药的治疗作用观察
- Author:
Changlin HUANG
;
Weiqiang YANG
- Publication Type:Journal Article
- Keywords:
femur head necrosis;
glucocorticoids;
bone-specific alkaline phosphatase;
osteocalcin;
tartrate-resistant acid phosphatase
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance of cell function changes of bone tissue in glucocorticoid-induced avascular necrosis of femoral head(GANFH),and the preventive and therapeutic effects of "Cugusugao" ointment,a mixture of traditional Chinese medicines,on GANFH.Methods Sixty-four New Zealand white rabbits were randomly divided into four groups(16 each): control group,model group,therapy group and prevention group.The contents of bone-specific alkaline phosphatase(BSAP) and bone gla protein(BGP),and the activity of tartrate-resistant acid phosphatase(TRAP) in serum were determined at the 0,2nd,4th,6th,8th and 12th week after treatment.Meanwhile,rabbits were sacrificed at the 4th,6th,8th and 12th week,and bilateral femoral heads were obtained for histopathological examination.Results Compared with control group,the contents of serum BSAP were elevated at the 4th and 6th week,while TRAP elevated from the 2nd week and BGP lowered from the 4th week in model group(P
