Changes of bone mineral in glucocorticoid-induced avascular necrosis of femoral head
- VernacularTitle:骨矿物盐在兔激素性股骨头坏死过程中的变化
- Author:
Weiqiang YANG
;
Changlin HUANG
- Publication Type:Journal Article
- Keywords:
femur head necrosis;
glucocorticoids;
bone density;
calcium;
phosphorus
- From:
Medical Journal of Chinese People's Liberation Army
1983;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of bone mineral changes in the pathogenic process of glucocorticoid-induced avascular necrosis of femoral head(GANFH).Methods Thirty-two New Zealand rabbits were randomly divided into two groups(16 each).Animals in model group received an intramuscular injection of hydrocortisone acetate(8.0mg/kg) twice a week for 8 weeks totally,and animals in control group received an intramuscular injection with the same volume of normal saline,while 150kU penicillin were injected twice a week for preventing infection in both groups.The contents of serum calcium(Ca) and phosphorus(P) were determined,and the bone mineral densities of the femoral head and neck were measured at the 2nd,4th,6th,8th and 12th weeks after treatment.Meanwhile,the general condition such as weight,spirit and hair of rabbits was observed.Results Compared with the control group,the weight of rabbits in model group lost since the first week,and progressively aggravated;the bone mineral density of the femoral head and neck lowered since the 2nd and 4th week respectively(P
