Effects of different TCM prescriptions of JinKuiYaoLve on the levels of Noradrenaline(NE),Dopamine(DA) and 5-hydroxytryptamine(5-HT) in lung and brain tissues of pulmonary fibrosis in the early stages
- VernacularTitle:《金匮要略》不同方药对肺纤维化模型早期阶段(7天)肺、脑组织NE、DA、5-HT含量的影响
- Author:
Jianping SONG
;
Wei LI
;
Ruiqin LI
;
Rui ZHANG
;
Junlian QIN
;
Jianming XU
;
Li TIAN
;
Lina MA
;
Limin ZHANG
- Publication Type:Journal Article
- Keywords:
Pulmonary fibrosis;
Gualouxiebai decoction(GLXB), Dahuangzhechong pills (DHZCW);
Shenqi pills(SQW);
Maimendong decoction(MMD);
Noradrenaline(NE);
Dopamine(DA);
5-hydroxytryptamine(5-HT)
- From:
China Journal of Traditional Chinese Medicine and Pharmacy
2005;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of different TCM prescriptions of JinKuiYaoLve on levels of noradrenaline(NE), dopamine(DA) and 5-hydroxytryptamine(5-HT) in lung and brain tissues of pulmonary fibrosis in the early stages. To investigate the effect and mechanism of TCM prescriptions and the nature of prescription-syndrome. Methods: The wistar rats were divided into groups randomly. Pulmonary fibrosis was induced by bleomycin A5 in all groups except normal group. Rats in drug group were killed after 7 days' treatment. The levels of NE, DA and 5-HT in the lung and brain tissues were detected. Results: The level of NE in the lung tissue of model group was higher than that of normal group, Gualouxiebai decoction(GLXB) group and prednisone group. The level of 5-HT of model group was lower than that of Shenqi Pills(SQW) group and prednisone group. The level of DA of SQW group was lower than that of GLXB group. The level of NE in the brain tissue of model group was higher than that of normal group, but the level of DA was lower than that of normal group, GLXB group and Maimendong decoction(MMD) group. The level of 5-HT of Dahuangzhechong pills (DHZCW) group was higher than that of other groups(P
