Progress in the relationship between mutant SOD1 and amyotrophic lateral sclerosis.
- VernacularTitle:SOD1基因与运动神经元病相关性的研究进展
- Author:
Xin QI
;
Liying CUI
- Publication Type:Journal Article
- Keywords:
amyotrophic lateral sclerosis;
SOD1;
gene
- From:
Chinese Journal of Practical Internal Medicine
2001;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disorder.Mutations in the Cu,Zn-superoxide dismutase(SOD1)gene cause ALS by an unknown gain-of-function mechanism.Current researches show that diminishing SOD1 mutation enzymatic activity does not account for motor neuron lose in ALS,while direct toxicity of variant SOD1 protein or aggregation of SOD1 protein may impart cell function and cause motor neuron death.Though motor neuron death is selective,other cells also participate in this course.The author reviewed recent advances in the relationship between mutant SOD1 and Amyotrophic Lateral Sclerosis.
