The expression and its clinical significances of interleukin-3 receptor alpha on Bone Marrow cells of the patients with acute myelocytic leukemia.
- VernacularTitle:白细胞介素-3受体?在急性髓性白血病原代骨髓细胞中的表达及其临床意义研究
- Author:
Haoran HU
;
Yong LIANG
;
Rong FU
;
Guojin WANG
;
Huaquan WANG
;
Limin XING
;
Wen QU
;
Jing GUAN
;
Yuhong WU
;
Hong LIU
;
Jia SONG
;
Yue REN
;
Hui LIU
;
Xiaoming WANG
;
Jun WANG
;
Lijuan LI
;
Erbao RUAN
;
Zonghong SHAO
- Publication Type:Journal Article
- Keywords: interleukin-3 receptor alpha; acute myeloid leukemia
- From: Chinese Journal of Practical Internal Medicine 2001;0(05):-
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the expression of interleukin-3 receptor alpha(CD123)on bone marrow cells in acute myelocytic leukemia(AML)and its clinical significances.Methods By means of Fluorescence-activated cell sorer(FACS)and semi-quantity reverse transcripition polymerase chain reaction(RT-PCR),the expression of IL-3R?(CD123+)protein on CD34+CD38-cells and mRNA in BMMNCs of 62 AML patients of Tianjin Medical University General Hospital from March 2008 to January 2009 and 12 normal controls were detected respectively;Then the correlation between IL-3R? and the clinical stages of AML were analyzed.Results CD34+CD38-CD123+/CD34+CD38-and IL-3R? mRNA in BMMNC of 33 deno-vo or relapsed AML patients were higher than those of control group(P