ANALYSIS OF THE RELATIONSHIP BETWEEN LIPOPROTEIN LIPASE GENE POLYMORPHISM AND BLOOD FAT TRAITS
- VernacularTitle:脂蛋白脂酶基因多态性与小鼠诱导性高血脂症敏感性的相关性分析
- Author:
Qin CHEN
;
Wenjun WANG
;
Jiaoyan LI
;
Huaying DU
;
Dan WANG
- Publication Type:Journal Article
- Keywords:
LPL gene,polymorphisim,hyperglycimia mice,blood-fat trait
- From:
Acta Nutrimenta Sinica
1956;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of diet and gene on blood-fat trait of the individual.Method One hundred and twenty mice were fed with high fat emulsion for 4 w,then the genotypes of LPL were analyzed by PCR-SSCP to investigate their effect on blood-fat traits and some organ performance of mice.Result After fed with high fat emulsion for 4 w,98 mice suffered from hyperlipidemia,while 22 mice did not.And a G/A mutation was found in 220 targeted fragments we amplified at 14355 site,and association analysis showed that the mice with BB genotype had higher TC、TG、LDL、H/W、L/W level than those of the mice with AA genotype(P
