Relationship between endothelin-1 gene polymorphisms and essential hypertension
- VernacularTitle:内皮素-1基因多态性与原发性高血压的相关性研究
- Author:
Liwei HANG
;
Zhihong WU
;
Zhen WANG
;
Guiwang DOU
;
Jiachun CAI
;
Jianzhong ZHOU
- Publication Type:Journal Article
- Keywords:
endothelin-1 gene;
polymorphism;
essential hypertension
- From:Journal of Third Military Medical University
2003;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between Lys198Asn and Taq Ⅰ polymorphisms of endothelin-1 gene and essential hypertension in Chongqing residents.Methods Polymorphisms of Lys198Asn and TaqⅠ were detected in the blood samples from 86 patients with essential hypertension(HT) and 138 normotensive controls(NT) by sequence specific primer-polymerase chain reaction(SSP-PCR) and PCR-restriction fragment length polymorphism(PCR-RFLP).Results In the BMI
